Pfizer's To Present Lung Cancer Data July 3-7

To contact us Click HERE
Image via CrunchBase Pfizer Inc. will present early and mid-stage data from its lung cancer portfolio, including PF-00299804 (PF-299) an investigational, oral, pan-HER inhibitor;¹ and crizotinib, an investigational, oral, first-in-class compound that inhibits the anaplastic lymphoma kinase, or ALK,² at the International Association for the Study of Lung Cancer’s (IASLC) 14^th World Conference on Lung Cancer (WCLC), July 3-7 in Amsterdam, The Netherlands.

“While lung cancer remains a difficult-to-treat disease, we’re learning more about how therapies like crizotinib and PF-299 may be able to specifically target ALK or the HER pathway, respectively, and how this may lead to more rationally selected and personalized therapy,” said Maurizio Voi, MD, Thoracic Tumor Strategy Lead, Pfizer Oncology. “Data being presented show survival outcomes for PF-299 and crizotinib, as well as quality-of-life or patient-reported outcomes after treatment for patients with non small cell lung cancer, which represent important considerations in determining the best treatment option for these patients.”

First Presentation of PF-299 Preliminary Overall Survival Data

Continued....

 
Pfizer will present, for the first time, preliminary overall survival data from a Phase 2 study evaluating PF-299 vs erlotinib in patients with advanced non-small cell lung cancer (NSCLC) after progression on at least one chemotherapy regimen (oral presentation, Abstract #745, Monday, July 4).¹
Pfizer also will present patient-reported outcomes (PRO) from clinical trials of PF-299 in refractory and second-/third-line NSCLC, which provide a better understanding of the patient’s perspective of the burden of adverse events associated with treatment and how it may change over time.^3,4

• Gastrointestinal toxicity of the pan-HER tyrosine kinase inhibitor (TKI) PF299804: Assessment by patient-reported outcomes in second-/third-line and refractory NSCLC (poster session, Abstract #957, Wednesday, July 6)³
• Dermatologic adverse events of the pan-HER tyrosine kinase inhibitor (TKI) PF299804: Assessment by patient-reported outcomes in second-/third-line and refractory NSCLC (poster session, Abstract #702, Wednesday, July 6)⁴

Based on results from across the PF-299 clinical trial program, Pfizer has initiated a Phase 3 trial, ARCHER 1009, evaluating PF-299 vs erlotinib for the treatment of patients with locally advanced or metastatic NSCLC following progression after, or intolerance to, at least one prior chemotherapy. ARCHER 1009 will assess the efficacy and safety of PF-299 in two co-primary populations: all enrolled patients, and enrolled patients with KRAS wild type status. The ARCHER 1009 study is open for enrollment in the US and will be enrolling soon in other countries.⁵
PF-299 targets multiple receptors of the HER pathway. PF-299 is an irreversible inhibitor of HER-1 (EGFR), HER-2 and HER-4 tyrosine kinases. ⁶
Crizotinib Data to be presented:
At the WCLC, data on the anti-tumor activity, safety, overall survival, patient-reported and quality-of-life outcomes observed in clinical trials of Pfizer’s crizotinib will be presented.^2,7,8

• Phase 2 data for crizotinib in ALK-positive advanced NSCLC: PROFILE 1005 (oral presentation, Abstract #1618, Wednesday, July 6)²
• PROFILE 1005: Preliminary patient-reported outcomes (PROs) from an ongoing Phase 2 study of crizotinib in ALK-positive advanced NSCLC (oral presentation, Abstract #1510, Wednesday, July 6)⁷
• Crizotinib improves overall survival of ALK-positive patients with advanced NSCLC compared with historical controls (oral presentation, Abstract #1207, Wednesday, July 6)⁸
• Efficacy of crizotinib in retrospective comparisons with standard-of-care (SOC) regimens from three Pfizer-sponsored clinical trials in patients with advanced NSCLC (poster session, Abstract #1349, Wednesday, July 6)⁹

Crizotinib is an investigational agent that inhibits ALK, ¹⁰ which blocks signaling in a number of cell pathways that are believed to be critical for the growth and survival of tumor cells.^11,12 Preliminary epidemiology suggests that approximately 3-5 percent of NSCLC tumors are ALK-positive.¹¹
About Pfizer Oncology
Pfizer Oncology is committed to the discovery, investigation and development of innovative treatment options to improve the outlook for cancer patients worldwide. Our strong pipeline, one of the most robust in the industry, is studied with precise focus on identifying and translating the best scientific breakthroughs into clinical application for patients across a wide range of cancers. Pfizer Oncology has biologics and small molecules in clinical development and more than 100 clinical trials underway. By working collaboratively with academic institutions, individual researchers, cooperative research groups, governments, and licensing partners, Pfizer Oncology strives to cure or control cancer with breakthrough medicines, to deliver the right drug for each patient at the right time. For more information please visit www.Pfizer.com.
DISCLOSURE NOTICE: The information contained in this release is as of June 28, 2011. Pfizer assumes no obligation to update forward-looking statements contained in this release as the result of new information or future events or developments.
This release contains forward-looking information about various oncology product candidates, including their potential benefits, that involves substantial risks and uncertainties. Such risks and uncertainties include, among other things, the uncertainties inherent in research and development; decisions by regulatory authorities regarding whether and when to approve any drug applications that have been or may be filed for any such oncology product candidates as well as their decisions regarding labeling and other matters that could affect their availability or commercial potential; and competitive developments.
A further description of risks and uncertainties can be found in Pfizer’s Annual Report on Form 10-K for the fiscal year ended December 31, 2010 and in its reports on Form 10-Q and Form 8-K.
¹ World Lung Accepted Abstract #745. Overall Survival (OS) Results of a Randomized Phase 2 Trial of PF299804 versus Erlotinib in Patients with Advanced Non-Small Cell Lung Cancer (NSCLC) After Failure of Chemotherapy. Oral Session, Monday July 4, 2011: 3:35 PM – 3:45 PM CEST. M. Boyer – Presenter. International Association for the Study of Lung Cancer’s (IASLC) 14th World Conference on Lung Cancer (WCLC), Amsterdam, The Netherlands. July 3-7, 2011.
² World Lung Accepted Abstract #1618. Phase 2 Data for Crizotinib (PF-02341066) in ALK-Positive Advanced Non-Small Cell Lung Cancer (NSCLC): PROFILE 1005. Oral Session, Wednesday July 6, 2011: 3:10 PM – 3:20 PM CEST. G. Riely – Presenter. International Association for the Study of Lung Cancer’s (IASLC) 14th World Conference on Lung Cancer (WCLC), Amsterdam, The Netherlands. July 3-7, 2011.
³ World Lung Accepted Abstract #957. Gastrointestinal Toxicity of the Pan-HER Tyrosine Kinase Inhibitor (TKI) PF299804: Assessment by Patient-Reported Outcomes in 2nd/3rd-Line and Refractory Non-Small Cell Lung Cancer (NSCLC). Poster Session, Wednesday July 6, 2011: 12:15 PM – 2:15 PM CEST. A. Campbell – Presenter. International Association for the Study of Lung Cancer’s (IASLC) 14th World Conference on Lung Cancer (WCLC), Amsterdam, The Netherlands. July 3-7, 2011.
⁴ World Lung Accepted Abstract #702. Dermatologic Adverse Events of the Pan-HER Tyrosine Kinase Inhibitor (TKI) PF299804: Assessment by Patient-Reported Outcomes in 2nd/3rd-line and Refractory Non-Small Cell Lung Cancer (NSCLC). Poster Session, Wednesday July 6, 2011: 12:15 PM – 2:15 PM CEST. A. Campbell – Presenter. International Association for the Study of Lung Cancer’s (IASLC) 14th World Conference on Lung Cancer (WCLC), Amsterdam, The Netherlands. July 3-7, 2011.
⁵ Clinicaltrials.gov. ARCHER 1009: A Phase 3 Study of PF-00299804, a Pan-HER Inhibitor, Vs. Erolotinib in the Treatment of Advanced Non-Small Cell Lung Cancer. Available here: http://www.clinicaltrials.gov/ct2/show/NCT01360554?term=ARCHER&rank=1. Accessed June 21, 2011.
⁶ Gonzales AJ, Hook KE, Althaus IW et al. Antitumor activity and pharmacokinetic properties of PF-00299804, a second-generation irreversible pan-erbBreceptor tyrosine kinase inhibitor. Mol Cancer Ther. 2008;7:1880-89.
⁷ World Lung Accepted Abstract #1510. PROFILE 1005: Preliminary Patient-Reported Outcomes (PROs) from an Ongoing Phase 2 Study of Crizotinib (PF-02341066) in Anaplastic Lymphoma Kinase (ALK)-Positive Advanced Non-Small Cell Lung Cancer (NSCLC). Oral Session, Wednesday July 6, 2011: 3:30 PM – 3:40 PM CEST. F. Blackhall – Presenter. Presenter. International Association for the Study of Lung Cancer’s (IASLC) 14th World Conference on Lung Cancer (WCLC), Amsterdam, The Netherlands. July 3-7, 2011.
⁸ World Lung Accepted Abstract #1207. Crizotinib improves overall survival of ALK-positive patients with advanced NSCLC compared with historical controls. Oral Session, Wednesday July 6, 2011: 3:20 PM – 3:30 PM CEST. A. Shaw – Presenter. International Association for the Study of Lung Cancer’s (IASLC) 14th World Conference on Lung Cancer (WCLC), Amsterdam, The Netherlands. July 3-7, 2011.
⁹ World Lung Accepted Abstract #1349. Efficacy of Crizotinib in Retrospective Comparisons with Standard-Of-Care (SOC) Regimens from Three Pfizer-Sponsored Clinical Trials in Patients with Advanced Non-Small Cell Lung Cancer (NSCLC). Poster Session, Wednesday July 6, 2011: 12:15 PM – 2:15 PM CEST. Y. Tang – Presenter. International Association for the Study of Lung Cancer’s (IASLC) 14th World Conference on Lung Cancer (WCLC), Amsterdam, The Netherlands. July 3-7, 2011.
¹⁰ Bang Y et al. Clinical Activity of the Oral ALK Inhibitor, Crizotinib (PF-02341066), in Patients with ALK-positive Non-Small Cell Lung Cancer. Accepted Plenary Presentation at the American Society of Clinical Oncology Annual Meeting, June 4-8, 2010. Chicago, IL.
¹¹ Zou HY, Li Q, Lee JH, et al. An orally available small-molecule inhibitor of c-MET,
PF-2341066, exhibits cytoreductive antitumor efficacy through antiproliferative and antiangiogenic mechanisms. Cancer Res. 2007;67:4408-4417.
¹² Chiarle R, Voena C, Ambrogio C et al. The anaplastic lymphoma kinase in the pathogenesis of cancer. Nat Rev Cancer. 2008;8(1): 11-23.

Related articles

• Pfizer Lung Cancer Drug to Get Priority Review (xconomy.com)
• Benefit of targeted lung cancer therapy confirmed (eurekalert.org)
• Pfizer drug shows double survival time for certain lung cancer patients (nj.com)
• Analyst bets on approval of Pfizer's lung cancer drug (fiercebiotech.com)

Boceprevir approved for use by Britain's state health service.

To contact us Click HERE
Merck’s new hepatitis C drug, Boceprevir (Victrelis) has won recommendation for use in Britain’s state health service. It was widely discussed especially because the drug is especially expensive. This an important drug because unlike previous INV +Ribavirin combination therapy, Boceprevir can be used in the treatment of hepatitis due to HCV genotype 1, the most common form of hepatitis C. It will be used in combination with Pegylated Interferon and Ribavirin for genotype 1 hepatitis C.

Boceprevir is an NS3/4A protease inhibitor. This drug stops viral replication by binding to a protease that would work to cleave the polyprotein. Thus this drug prevents the production of functional viral protein. Pegylated interferons are used to moderate the immune system. Ribivirin is a nucleoside analog and when given with IFN, it can reduce viral replication.

Original Article from Reuters: http://www.reuters.com/article/2012/03/09/merck-britain-idUSL5E8E8AH120120309

More info on HCV Medications:
http://emedicine.medscape.com/article/177792-medication#2

--Elena Jordan

What's your Drinking Personality?

To contact us Click HERE
The BBC is running a fluffy piece on peoples drinking personalities. It seems a psychologist, Dr. Glenn Willson, has observed the behavior of 500 Brits while at bars and pubs and found that their body language belies their personality. The good doctor has determined that their are eight distinct "drinking personalities". No more, no less.

From the article:

THE JACK-THE-LAD

This "peacock" is conscious of his image and will drink a bottled beer, or cider.

He is inclined to be confident and arrogant, and can be territorial in his gestures, spreading himself over as much space as possible, for example, pushing the glass well away from himself and leaning back in his chair.

If he is drinking with friends, he would be unlikely to welcome approaches from outside the group, unless sycophantic and ego-enhancing.

So, what's your drinking personality? I think I am clearly the "Ice Queen."

Image via the BBC.

Pfizer's To Present Lung Cancer Data July 3-7

To contact us Click HERE
Image via CrunchBase Pfizer Inc. will present early and mid-stage data from its lung cancer portfolio, including PF-00299804 (PF-299) an investigational, oral, pan-HER inhibitor;¹ and crizotinib, an investigational, oral, first-in-class compound that inhibits the anaplastic lymphoma kinase, or ALK,² at the International Association for the Study of Lung Cancer’s (IASLC) 14^th World Conference on Lung Cancer (WCLC), July 3-7 in Amsterdam, The Netherlands.

“While lung cancer remains a difficult-to-treat disease, we’re learning more about how therapies like crizotinib and PF-299 may be able to specifically target ALK or the HER pathway, respectively, and how this may lead to more rationally selected and personalized therapy,” said Maurizio Voi, MD, Thoracic Tumor Strategy Lead, Pfizer Oncology. “Data being presented show survival outcomes for PF-299 and crizotinib, as well as quality-of-life or patient-reported outcomes after treatment for patients with non small cell lung cancer, which represent important considerations in determining the best treatment option for these patients.”

First Presentation of PF-299 Preliminary Overall Survival Data

Continued....

 
Pfizer will present, for the first time, preliminary overall survival data from a Phase 2 study evaluating PF-299 vs erlotinib in patients with advanced non-small cell lung cancer (NSCLC) after progression on at least one chemotherapy regimen (oral presentation, Abstract #745, Monday, July 4).¹
Pfizer also will present patient-reported outcomes (PRO) from clinical trials of PF-299 in refractory and second-/third-line NSCLC, which provide a better understanding of the patient’s perspective of the burden of adverse events associated with treatment and how it may change over time.^3,4

• Gastrointestinal toxicity of the pan-HER tyrosine kinase inhibitor (TKI) PF299804: Assessment by patient-reported outcomes in second-/third-line and refractory NSCLC (poster session, Abstract #957, Wednesday, July 6)³
• Dermatologic adverse events of the pan-HER tyrosine kinase inhibitor (TKI) PF299804: Assessment by patient-reported outcomes in second-/third-line and refractory NSCLC (poster session, Abstract #702, Wednesday, July 6)⁴

Based on results from across the PF-299 clinical trial program, Pfizer has initiated a Phase 3 trial, ARCHER 1009, evaluating PF-299 vs erlotinib for the treatment of patients with locally advanced or metastatic NSCLC following progression after, or intolerance to, at least one prior chemotherapy. ARCHER 1009 will assess the efficacy and safety of PF-299 in two co-primary populations: all enrolled patients, and enrolled patients with KRAS wild type status. The ARCHER 1009 study is open for enrollment in the US and will be enrolling soon in other countries.⁵
PF-299 targets multiple receptors of the HER pathway. PF-299 is an irreversible inhibitor of HER-1 (EGFR), HER-2 and HER-4 tyrosine kinases. ⁶
Crizotinib Data to be presented:
At the WCLC, data on the anti-tumor activity, safety, overall survival, patient-reported and quality-of-life outcomes observed in clinical trials of Pfizer’s crizotinib will be presented.^2,7,8

• Phase 2 data for crizotinib in ALK-positive advanced NSCLC: PROFILE 1005 (oral presentation, Abstract #1618, Wednesday, July 6)²
• PROFILE 1005: Preliminary patient-reported outcomes (PROs) from an ongoing Phase 2 study of crizotinib in ALK-positive advanced NSCLC (oral presentation, Abstract #1510, Wednesday, July 6)⁷
• Crizotinib improves overall survival of ALK-positive patients with advanced NSCLC compared with historical controls (oral presentation, Abstract #1207, Wednesday, July 6)⁸
• Efficacy of crizotinib in retrospective comparisons with standard-of-care (SOC) regimens from three Pfizer-sponsored clinical trials in patients with advanced NSCLC (poster session, Abstract #1349, Wednesday, July 6)⁹

Crizotinib is an investigational agent that inhibits ALK, ¹⁰ which blocks signaling in a number of cell pathways that are believed to be critical for the growth and survival of tumor cells.^11,12 Preliminary epidemiology suggests that approximately 3-5 percent of NSCLC tumors are ALK-positive.¹¹
About Pfizer Oncology
Pfizer Oncology is committed to the discovery, investigation and development of innovative treatment options to improve the outlook for cancer patients worldwide. Our strong pipeline, one of the most robust in the industry, is studied with precise focus on identifying and translating the best scientific breakthroughs into clinical application for patients across a wide range of cancers. Pfizer Oncology has biologics and small molecules in clinical development and more than 100 clinical trials underway. By working collaboratively with academic institutions, individual researchers, cooperative research groups, governments, and licensing partners, Pfizer Oncology strives to cure or control cancer with breakthrough medicines, to deliver the right drug for each patient at the right time. For more information please visit www.Pfizer.com.
DISCLOSURE NOTICE: The information contained in this release is as of June 28, 2011. Pfizer assumes no obligation to update forward-looking statements contained in this release as the result of new information or future events or developments.
This release contains forward-looking information about various oncology product candidates, including their potential benefits, that involves substantial risks and uncertainties. Such risks and uncertainties include, among other things, the uncertainties inherent in research and development; decisions by regulatory authorities regarding whether and when to approve any drug applications that have been or may be filed for any such oncology product candidates as well as their decisions regarding labeling and other matters that could affect their availability or commercial potential; and competitive developments.
A further description of risks and uncertainties can be found in Pfizer’s Annual Report on Form 10-K for the fiscal year ended December 31, 2010 and in its reports on Form 10-Q and Form 8-K.
¹ World Lung Accepted Abstract #745. Overall Survival (OS) Results of a Randomized Phase 2 Trial of PF299804 versus Erlotinib in Patients with Advanced Non-Small Cell Lung Cancer (NSCLC) After Failure of Chemotherapy. Oral Session, Monday July 4, 2011: 3:35 PM – 3:45 PM CEST. M. Boyer – Presenter. International Association for the Study of Lung Cancer’s (IASLC) 14th World Conference on Lung Cancer (WCLC), Amsterdam, The Netherlands. July 3-7, 2011.
² World Lung Accepted Abstract #1618. Phase 2 Data for Crizotinib (PF-02341066) in ALK-Positive Advanced Non-Small Cell Lung Cancer (NSCLC): PROFILE 1005. Oral Session, Wednesday July 6, 2011: 3:10 PM – 3:20 PM CEST. G. Riely – Presenter. International Association for the Study of Lung Cancer’s (IASLC) 14th World Conference on Lung Cancer (WCLC), Amsterdam, The Netherlands. July 3-7, 2011.
³ World Lung Accepted Abstract #957. Gastrointestinal Toxicity of the Pan-HER Tyrosine Kinase Inhibitor (TKI) PF299804: Assessment by Patient-Reported Outcomes in 2nd/3rd-Line and Refractory Non-Small Cell Lung Cancer (NSCLC). Poster Session, Wednesday July 6, 2011: 12:15 PM – 2:15 PM CEST. A. Campbell – Presenter. International Association for the Study of Lung Cancer’s (IASLC) 14th World Conference on Lung Cancer (WCLC), Amsterdam, The Netherlands. July 3-7, 2011.
⁴ World Lung Accepted Abstract #702. Dermatologic Adverse Events of the Pan-HER Tyrosine Kinase Inhibitor (TKI) PF299804: Assessment by Patient-Reported Outcomes in 2nd/3rd-line and Refractory Non-Small Cell Lung Cancer (NSCLC). Poster Session, Wednesday July 6, 2011: 12:15 PM – 2:15 PM CEST. A. Campbell – Presenter. International Association for the Study of Lung Cancer’s (IASLC) 14th World Conference on Lung Cancer (WCLC), Amsterdam, The Netherlands. July 3-7, 2011.
⁵ Clinicaltrials.gov. ARCHER 1009: A Phase 3 Study of PF-00299804, a Pan-HER Inhibitor, Vs. Erolotinib in the Treatment of Advanced Non-Small Cell Lung Cancer. Available here: http://www.clinicaltrials.gov/ct2/show/NCT01360554?term=ARCHER&rank=1. Accessed June 21, 2011.
⁶ Gonzales AJ, Hook KE, Althaus IW et al. Antitumor activity and pharmacokinetic properties of PF-00299804, a second-generation irreversible pan-erbBreceptor tyrosine kinase inhibitor. Mol Cancer Ther. 2008;7:1880-89.
⁷ World Lung Accepted Abstract #1510. PROFILE 1005: Preliminary Patient-Reported Outcomes (PROs) from an Ongoing Phase 2 Study of Crizotinib (PF-02341066) in Anaplastic Lymphoma Kinase (ALK)-Positive Advanced Non-Small Cell Lung Cancer (NSCLC). Oral Session, Wednesday July 6, 2011: 3:30 PM – 3:40 PM CEST. F. Blackhall – Presenter. Presenter. International Association for the Study of Lung Cancer’s (IASLC) 14th World Conference on Lung Cancer (WCLC), Amsterdam, The Netherlands. July 3-7, 2011.
⁸ World Lung Accepted Abstract #1207. Crizotinib improves overall survival of ALK-positive patients with advanced NSCLC compared with historical controls. Oral Session, Wednesday July 6, 2011: 3:20 PM – 3:30 PM CEST. A. Shaw – Presenter. International Association for the Study of Lung Cancer’s (IASLC) 14th World Conference on Lung Cancer (WCLC), Amsterdam, The Netherlands. July 3-7, 2011.
⁹ World Lung Accepted Abstract #1349. Efficacy of Crizotinib in Retrospective Comparisons with Standard-Of-Care (SOC) Regimens from Three Pfizer-Sponsored Clinical Trials in Patients with Advanced Non-Small Cell Lung Cancer (NSCLC). Poster Session, Wednesday July 6, 2011: 12:15 PM – 2:15 PM CEST. Y. Tang – Presenter. International Association for the Study of Lung Cancer’s (IASLC) 14th World Conference on Lung Cancer (WCLC), Amsterdam, The Netherlands. July 3-7, 2011.
¹⁰ Bang Y et al. Clinical Activity of the Oral ALK Inhibitor, Crizotinib (PF-02341066), in Patients with ALK-positive Non-Small Cell Lung Cancer. Accepted Plenary Presentation at the American Society of Clinical Oncology Annual Meeting, June 4-8, 2010. Chicago, IL.
¹¹ Zou HY, Li Q, Lee JH, et al. An orally available small-molecule inhibitor of c-MET,
PF-2341066, exhibits cytoreductive antitumor efficacy through antiproliferative and antiangiogenic mechanisms. Cancer Res. 2007;67:4408-4417.
¹² Chiarle R, Voena C, Ambrogio C et al. The anaplastic lymphoma kinase in the pathogenesis of cancer. Nat Rev Cancer. 2008;8(1): 11-23.

Related articles

• Pfizer Lung Cancer Drug to Get Priority Review (xconomy.com)
• Benefit of targeted lung cancer therapy confirmed (eurekalert.org)
• Pfizer drug shows double survival time for certain lung cancer patients (nj.com)
• Analyst bets on approval of Pfizer's lung cancer drug (fiercebiotech.com)

NOVEMBER 29, 2012 EPA/DHA

To contact us Click HERE

The process of becoming changed begins with awareness. "

There are the 3 big A's in life - awareness- the first; then acknowledgment and finally the hardest of all three in my opinion is acceptance. For me, some 19 years ago --to accept that I had a problem with alcohol and substances was difficult. I rationalized- I should have known better.  I would say , " There is no alcoholic in my family or I do not drink all the time."
With the help assistance of the founder of AA's principles, Bill W. and his large heavy blue book, Alcoholics Anonymous, I slowly began to change.
Today, I have no troubles...NOT-- We all living on this Earth have some type of problem whether small, large or huge. But I will say this- my worst day today in 2012 is better than any day prior to doing the step work in AA.

The need for omega 3 fatty acids in human health is well understood. You must realize that your diet is deficient in omega 3 while not in omega 6 fatty acids.

You must supplement fish oils in an effort to boost omega 3 fatty acid intake The supplementation must come from a fish source. This has clearly been demonstrated. Sure you have the tuna ( it might contain mercury) the halibut and the mackerel. Squid is another source. But lately there are studies on krill oil from these shrimp like crustaceans. There are high amounts of EPA and DHA in krill oil.

If you are one of these individuals who cannot use fish oil, you have a problem. You might say to the doctor that you use Flaxseed Oil. I think this is terrific but flax contains 52 - 55% omega3's as alpha linolenic acid ( ALA) not EPA / DHA. Also do not confuse the abbreviation ALA to stand for alpha lipoic acid.  It does not.

Medical conditions that may be treated or prevented with fish oil.
1. High triglycerides
2. Coronary artery disease
3. Heart Failure
4. Asthma
5. Rheumatoid arthritis
6. Bipolar disorder
7. Inflammatory bowel disease
8. Depression

If this isn't enough there is
1. Muscle sorness after exercise
2. Raynaud's phenomena
3. Dysmenorrhea
4. Dementia
5. Renal disease in IgA nephropathy

The take home message: Take some fish oils today

Until tomorrow...

Boceprevir approved for use by Britain's state health service.

To contact us Click HERE
Merck’s new hepatitis C drug, Boceprevir (Victrelis) has won recommendation for use in Britain’s state health service. It was widely discussed especially because the drug is especially expensive. This an important drug because unlike previous INV +Ribavirin combination therapy, Boceprevir can be used in the treatment of hepatitis due to HCV genotype 1, the most common form of hepatitis C. It will be used in combination with Pegylated Interferon and Ribavirin for genotype 1 hepatitis C.

Boceprevir is an NS3/4A protease inhibitor. This drug stops viral replication by binding to a protease that would work to cleave the polyprotein. Thus this drug prevents the production of functional viral protein. Pegylated interferons are used to moderate the immune system. Ribivirin is a nucleoside analog and when given with IFN, it can reduce viral replication.

Original Article from Reuters: http://www.reuters.com/article/2012/03/09/merck-britain-idUSL5E8E8AH120120309

More info on HCV Medications:
http://emedicine.medscape.com/article/177792-medication#2

--Elena Jordan

What's your Drinking Personality?

To contact us Click HERE
The BBC is running a fluffy piece on peoples drinking personalities. It seems a psychologist, Dr. Glenn Willson, has observed the behavior of 500 Brits while at bars and pubs and found that their body language belies their personality. The good doctor has determined that their are eight distinct "drinking personalities". No more, no less.

From the article:

THE JACK-THE-LAD

This "peacock" is conscious of his image and will drink a bottled beer, or cider.

He is inclined to be confident and arrogant, and can be territorial in his gestures, spreading himself over as much space as possible, for example, pushing the glass well away from himself and leaning back in his chair.

If he is drinking with friends, he would be unlikely to welcome approaches from outside the group, unless sycophantic and ego-enhancing.

So, what's your drinking personality? I think I am clearly the "Ice Queen."

Image via the BBC.

What's your Drinking Personality?

To contact us Click HERE
The BBC is running a fluffy piece on peoples drinking personalities. It seems a psychologist, Dr. Glenn Willson, has observed the behavior of 500 Brits while at bars and pubs and found that their body language belies their personality. The good doctor has determined that their are eight distinct "drinking personalities". No more, no less.

From the article:

THE JACK-THE-LAD

This "peacock" is conscious of his image and will drink a bottled beer, or cider.

He is inclined to be confident and arrogant, and can be territorial in his gestures, spreading himself over as much space as possible, for example, pushing the glass well away from himself and leaning back in his chair.

If he is drinking with friends, he would be unlikely to welcome approaches from outside the group, unless sycophantic and ego-enhancing.

So, what's your drinking personality? I think I am clearly the "Ice Queen."

Image via the BBC.

Boceprevir approved for use by Britain's state health service.

To contact us Click HERE
Merck’s new hepatitis C drug, Boceprevir (Victrelis) has won recommendation for use in Britain’s state health service. It was widely discussed especially because the drug is especially expensive. This an important drug because unlike previous INV +Ribavirin combination therapy, Boceprevir can be used in the treatment of hepatitis due to HCV genotype 1, the most common form of hepatitis C. It will be used in combination with Pegylated Interferon and Ribavirin for genotype 1 hepatitis C.

Boceprevir is an NS3/4A protease inhibitor. This drug stops viral replication by binding to a protease that would work to cleave the polyprotein. Thus this drug prevents the production of functional viral protein. Pegylated interferons are used to moderate the immune system. Ribivirin is a nucleoside analog and when given with IFN, it can reduce viral replication.

Original Article from Reuters: http://www.reuters.com/article/2012/03/09/merck-britain-idUSL5E8E8AH120120309

More info on HCV Medications:
http://emedicine.medscape.com/article/177792-medication#2

--Elena Jordan

Pfizer's To Present Lung Cancer Data July 3-7

To contact us Click HERE
Image via CrunchBase Pfizer Inc. will present early and mid-stage data from its lung cancer portfolio, including PF-00299804 (PF-299) an investigational, oral, pan-HER inhibitor;¹ and crizotinib, an investigational, oral, first-in-class compound that inhibits the anaplastic lymphoma kinase, or ALK,² at the International Association for the Study of Lung Cancer’s (IASLC) 14^th World Conference on Lung Cancer (WCLC), July 3-7 in Amsterdam, The Netherlands.

“While lung cancer remains a difficult-to-treat disease, we’re learning more about how therapies like crizotinib and PF-299 may be able to specifically target ALK or the HER pathway, respectively, and how this may lead to more rationally selected and personalized therapy,” said Maurizio Voi, MD, Thoracic Tumor Strategy Lead, Pfizer Oncology. “Data being presented show survival outcomes for PF-299 and crizotinib, as well as quality-of-life or patient-reported outcomes after treatment for patients with non small cell lung cancer, which represent important considerations in determining the best treatment option for these patients.”

First Presentation of PF-299 Preliminary Overall Survival Data

Continued....

 
Pfizer will present, for the first time, preliminary overall survival data from a Phase 2 study evaluating PF-299 vs erlotinib in patients with advanced non-small cell lung cancer (NSCLC) after progression on at least one chemotherapy regimen (oral presentation, Abstract #745, Monday, July 4).¹
Pfizer also will present patient-reported outcomes (PRO) from clinical trials of PF-299 in refractory and second-/third-line NSCLC, which provide a better understanding of the patient’s perspective of the burden of adverse events associated with treatment and how it may change over time.^3,4

• Gastrointestinal toxicity of the pan-HER tyrosine kinase inhibitor (TKI) PF299804: Assessment by patient-reported outcomes in second-/third-line and refractory NSCLC (poster session, Abstract #957, Wednesday, July 6)³
• Dermatologic adverse events of the pan-HER tyrosine kinase inhibitor (TKI) PF299804: Assessment by patient-reported outcomes in second-/third-line and refractory NSCLC (poster session, Abstract #702, Wednesday, July 6)⁴

Based on results from across the PF-299 clinical trial program, Pfizer has initiated a Phase 3 trial, ARCHER 1009, evaluating PF-299 vs erlotinib for the treatment of patients with locally advanced or metastatic NSCLC following progression after, or intolerance to, at least one prior chemotherapy. ARCHER 1009 will assess the efficacy and safety of PF-299 in two co-primary populations: all enrolled patients, and enrolled patients with KRAS wild type status. The ARCHER 1009 study is open for enrollment in the US and will be enrolling soon in other countries.⁵
PF-299 targets multiple receptors of the HER pathway. PF-299 is an irreversible inhibitor of HER-1 (EGFR), HER-2 and HER-4 tyrosine kinases. ⁶
Crizotinib Data to be presented:
At the WCLC, data on the anti-tumor activity, safety, overall survival, patient-reported and quality-of-life outcomes observed in clinical trials of Pfizer’s crizotinib will be presented.^2,7,8

• Phase 2 data for crizotinib in ALK-positive advanced NSCLC: PROFILE 1005 (oral presentation, Abstract #1618, Wednesday, July 6)²
• PROFILE 1005: Preliminary patient-reported outcomes (PROs) from an ongoing Phase 2 study of crizotinib in ALK-positive advanced NSCLC (oral presentation, Abstract #1510, Wednesday, July 6)⁷
• Crizotinib improves overall survival of ALK-positive patients with advanced NSCLC compared with historical controls (oral presentation, Abstract #1207, Wednesday, July 6)⁸
• Efficacy of crizotinib in retrospective comparisons with standard-of-care (SOC) regimens from three Pfizer-sponsored clinical trials in patients with advanced NSCLC (poster session, Abstract #1349, Wednesday, July 6)⁹

Crizotinib is an investigational agent that inhibits ALK, ¹⁰ which blocks signaling in a number of cell pathways that are believed to be critical for the growth and survival of tumor cells.^11,12 Preliminary epidemiology suggests that approximately 3-5 percent of NSCLC tumors are ALK-positive.¹¹
About Pfizer Oncology
Pfizer Oncology is committed to the discovery, investigation and development of innovative treatment options to improve the outlook for cancer patients worldwide. Our strong pipeline, one of the most robust in the industry, is studied with precise focus on identifying and translating the best scientific breakthroughs into clinical application for patients across a wide range of cancers. Pfizer Oncology has biologics and small molecules in clinical development and more than 100 clinical trials underway. By working collaboratively with academic institutions, individual researchers, cooperative research groups, governments, and licensing partners, Pfizer Oncology strives to cure or control cancer with breakthrough medicines, to deliver the right drug for each patient at the right time. For more information please visit www.Pfizer.com.
DISCLOSURE NOTICE: The information contained in this release is as of June 28, 2011. Pfizer assumes no obligation to update forward-looking statements contained in this release as the result of new information or future events or developments.
This release contains forward-looking information about various oncology product candidates, including their potential benefits, that involves substantial risks and uncertainties. Such risks and uncertainties include, among other things, the uncertainties inherent in research and development; decisions by regulatory authorities regarding whether and when to approve any drug applications that have been or may be filed for any such oncology product candidates as well as their decisions regarding labeling and other matters that could affect their availability or commercial potential; and competitive developments.
A further description of risks and uncertainties can be found in Pfizer’s Annual Report on Form 10-K for the fiscal year ended December 31, 2010 and in its reports on Form 10-Q and Form 8-K.
¹ World Lung Accepted Abstract #745. Overall Survival (OS) Results of a Randomized Phase 2 Trial of PF299804 versus Erlotinib in Patients with Advanced Non-Small Cell Lung Cancer (NSCLC) After Failure of Chemotherapy. Oral Session, Monday July 4, 2011: 3:35 PM – 3:45 PM CEST. M. Boyer – Presenter. International Association for the Study of Lung Cancer’s (IASLC) 14th World Conference on Lung Cancer (WCLC), Amsterdam, The Netherlands. July 3-7, 2011.
² World Lung Accepted Abstract #1618. Phase 2 Data for Crizotinib (PF-02341066) in ALK-Positive Advanced Non-Small Cell Lung Cancer (NSCLC): PROFILE 1005. Oral Session, Wednesday July 6, 2011: 3:10 PM – 3:20 PM CEST. G. Riely – Presenter. International Association for the Study of Lung Cancer’s (IASLC) 14th World Conference on Lung Cancer (WCLC), Amsterdam, The Netherlands. July 3-7, 2011.
³ World Lung Accepted Abstract #957. Gastrointestinal Toxicity of the Pan-HER Tyrosine Kinase Inhibitor (TKI) PF299804: Assessment by Patient-Reported Outcomes in 2nd/3rd-Line and Refractory Non-Small Cell Lung Cancer (NSCLC). Poster Session, Wednesday July 6, 2011: 12:15 PM – 2:15 PM CEST. A. Campbell – Presenter. International Association for the Study of Lung Cancer’s (IASLC) 14th World Conference on Lung Cancer (WCLC), Amsterdam, The Netherlands. July 3-7, 2011.
⁴ World Lung Accepted Abstract #702. Dermatologic Adverse Events of the Pan-HER Tyrosine Kinase Inhibitor (TKI) PF299804: Assessment by Patient-Reported Outcomes in 2nd/3rd-line and Refractory Non-Small Cell Lung Cancer (NSCLC). Poster Session, Wednesday July 6, 2011: 12:15 PM – 2:15 PM CEST. A. Campbell – Presenter. International Association for the Study of Lung Cancer’s (IASLC) 14th World Conference on Lung Cancer (WCLC), Amsterdam, The Netherlands. July 3-7, 2011.
⁵ Clinicaltrials.gov. ARCHER 1009: A Phase 3 Study of PF-00299804, a Pan-HER Inhibitor, Vs. Erolotinib in the Treatment of Advanced Non-Small Cell Lung Cancer. Available here: http://www.clinicaltrials.gov/ct2/show/NCT01360554?term=ARCHER&rank=1. Accessed June 21, 2011.
⁶ Gonzales AJ, Hook KE, Althaus IW et al. Antitumor activity and pharmacokinetic properties of PF-00299804, a second-generation irreversible pan-erbBreceptor tyrosine kinase inhibitor. Mol Cancer Ther. 2008;7:1880-89.
⁷ World Lung Accepted Abstract #1510. PROFILE 1005: Preliminary Patient-Reported Outcomes (PROs) from an Ongoing Phase 2 Study of Crizotinib (PF-02341066) in Anaplastic Lymphoma Kinase (ALK)-Positive Advanced Non-Small Cell Lung Cancer (NSCLC). Oral Session, Wednesday July 6, 2011: 3:30 PM – 3:40 PM CEST. F. Blackhall – Presenter. Presenter. International Association for the Study of Lung Cancer’s (IASLC) 14th World Conference on Lung Cancer (WCLC), Amsterdam, The Netherlands. July 3-7, 2011.
⁸ World Lung Accepted Abstract #1207. Crizotinib improves overall survival of ALK-positive patients with advanced NSCLC compared with historical controls. Oral Session, Wednesday July 6, 2011: 3:20 PM – 3:30 PM CEST. A. Shaw – Presenter. International Association for the Study of Lung Cancer’s (IASLC) 14th World Conference on Lung Cancer (WCLC), Amsterdam, The Netherlands. July 3-7, 2011.
⁹ World Lung Accepted Abstract #1349. Efficacy of Crizotinib in Retrospective Comparisons with Standard-Of-Care (SOC) Regimens from Three Pfizer-Sponsored Clinical Trials in Patients with Advanced Non-Small Cell Lung Cancer (NSCLC). Poster Session, Wednesday July 6, 2011: 12:15 PM – 2:15 PM CEST. Y. Tang – Presenter. International Association for the Study of Lung Cancer’s (IASLC) 14th World Conference on Lung Cancer (WCLC), Amsterdam, The Netherlands. July 3-7, 2011.
¹⁰ Bang Y et al. Clinical Activity of the Oral ALK Inhibitor, Crizotinib (PF-02341066), in Patients with ALK-positive Non-Small Cell Lung Cancer. Accepted Plenary Presentation at the American Society of Clinical Oncology Annual Meeting, June 4-8, 2010. Chicago, IL.
¹¹ Zou HY, Li Q, Lee JH, et al. An orally available small-molecule inhibitor of c-MET,
PF-2341066, exhibits cytoreductive antitumor efficacy through antiproliferative and antiangiogenic mechanisms. Cancer Res. 2007;67:4408-4417.
¹² Chiarle R, Voena C, Ambrogio C et al. The anaplastic lymphoma kinase in the pathogenesis of cancer. Nat Rev Cancer. 2008;8(1): 11-23.

Related articles

• Pfizer Lung Cancer Drug to Get Priority Review (xconomy.com)
• Benefit of targeted lung cancer therapy confirmed (eurekalert.org)
• Pfizer drug shows double survival time for certain lung cancer patients (nj.com)
• Analyst bets on approval of Pfizer's lung cancer drug (fiercebiotech.com)

NOVEMBER 28, 2012 LOW MAGNESIUM

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' GRATITUDE CONSISTS OF BEING MORE AWARE OF WHAT YOU HAVE THAN WHAT YOU DON'T.'

What you do have ? You hopefully have your health. You have the ability to read this blog. You hopefully have some sense of serenity . So YOU DON'T have the winning lottery ticket .. so what; So YOU DON'T have the dream house you always wanted.. so what; It is not about materialistic things you do and don;t have. It is about GRATITUDE NOT ATTITUDE!!!

Colo rectal cancer is the third leading cause of cancer related deaths in the United States.The lifetime risk in developing colon cancer is 1 in 20 or 5.1 %
There are many causes of developing colon cancer. There will be reports of a high red meat diet to a diet high in fat. Whatever you know, there is something you do not know

Recently published in August 2012 in The American Journal of Clinical Nutrition an inverse relationship was studied and investigated on low magnesium to higher risk of Colo rectal carcinoma.

It was a large study population. The conclusion supports the hypothesis that higher intakes of dietary magnesium are associated with a lower risk of Colo rectal tumors.

We need to explore the magnesium rich foods that may be cancer preventing. I do know there is a current study in a New York City Hospital using green tea in patients with Colo rectal cancer 

Until tomorrow...

What's your Drinking Personality?

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The BBC is running a fluffy piece on peoples drinking personalities. It seems a psychologist, Dr. Glenn Willson, has observed the behavior of 500 Brits while at bars and pubs and found that their body language belies their personality. The good doctor has determined that their are eight distinct "drinking personalities". No more, no less.

From the article:

THE JACK-THE-LAD

This "peacock" is conscious of his image and will drink a bottled beer, or cider.

He is inclined to be confident and arrogant, and can be territorial in his gestures, spreading himself over as much space as possible, for example, pushing the glass well away from himself and leaning back in his chair.

If he is drinking with friends, he would be unlikely to welcome approaches from outside the group, unless sycophantic and ego-enhancing.

So, what's your drinking personality? I think I am clearly the "Ice Queen."

Image via the BBC.

Boceprevir approved for use by Britain's state health service.

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Merck’s new hepatitis C drug, Boceprevir (Victrelis) has won recommendation for use in Britain’s state health service. It was widely discussed especially because the drug is especially expensive. This an important drug because unlike previous INV +Ribavirin combination therapy, Boceprevir can be used in the treatment of hepatitis due to HCV genotype 1, the most common form of hepatitis C. It will be used in combination with Pegylated Interferon and Ribavirin for genotype 1 hepatitis C.

Boceprevir is an NS3/4A protease inhibitor. This drug stops viral replication by binding to a protease that would work to cleave the polyprotein. Thus this drug prevents the production of functional viral protein. Pegylated interferons are used to moderate the immune system. Ribivirin is a nucleoside analog and when given with IFN, it can reduce viral replication.

Original Article from Reuters: http://www.reuters.com/article/2012/03/09/merck-britain-idUSL5E8E8AH120120309

More info on HCV Medications:
http://emedicine.medscape.com/article/177792-medication#2

--Elena Jordan

Pfizer's To Present Lung Cancer Data July 3-7

To contact us Click HERE
Image via CrunchBase Pfizer Inc. will present early and mid-stage data from its lung cancer portfolio, including PF-00299804 (PF-299) an investigational, oral, pan-HER inhibitor;¹ and crizotinib, an investigational, oral, first-in-class compound that inhibits the anaplastic lymphoma kinase, or ALK,² at the International Association for the Study of Lung Cancer’s (IASLC) 14^th World Conference on Lung Cancer (WCLC), July 3-7 in Amsterdam, The Netherlands.

“While lung cancer remains a difficult-to-treat disease, we’re learning more about how therapies like crizotinib and PF-299 may be able to specifically target ALK or the HER pathway, respectively, and how this may lead to more rationally selected and personalized therapy,” said Maurizio Voi, MD, Thoracic Tumor Strategy Lead, Pfizer Oncology. “Data being presented show survival outcomes for PF-299 and crizotinib, as well as quality-of-life or patient-reported outcomes after treatment for patients with non small cell lung cancer, which represent important considerations in determining the best treatment option for these patients.”

First Presentation of PF-299 Preliminary Overall Survival Data

Continued....

 
Pfizer will present, for the first time, preliminary overall survival data from a Phase 2 study evaluating PF-299 vs erlotinib in patients with advanced non-small cell lung cancer (NSCLC) after progression on at least one chemotherapy regimen (oral presentation, Abstract #745, Monday, July 4).¹
Pfizer also will present patient-reported outcomes (PRO) from clinical trials of PF-299 in refractory and second-/third-line NSCLC, which provide a better understanding of the patient’s perspective of the burden of adverse events associated with treatment and how it may change over time.^3,4

• Gastrointestinal toxicity of the pan-HER tyrosine kinase inhibitor (TKI) PF299804: Assessment by patient-reported outcomes in second-/third-line and refractory NSCLC (poster session, Abstract #957, Wednesday, July 6)³
• Dermatologic adverse events of the pan-HER tyrosine kinase inhibitor (TKI) PF299804: Assessment by patient-reported outcomes in second-/third-line and refractory NSCLC (poster session, Abstract #702, Wednesday, July 6)⁴

Based on results from across the PF-299 clinical trial program, Pfizer has initiated a Phase 3 trial, ARCHER 1009, evaluating PF-299 vs erlotinib for the treatment of patients with locally advanced or metastatic NSCLC following progression after, or intolerance to, at least one prior chemotherapy. ARCHER 1009 will assess the efficacy and safety of PF-299 in two co-primary populations: all enrolled patients, and enrolled patients with KRAS wild type status. The ARCHER 1009 study is open for enrollment in the US and will be enrolling soon in other countries.⁵
PF-299 targets multiple receptors of the HER pathway. PF-299 is an irreversible inhibitor of HER-1 (EGFR), HER-2 and HER-4 tyrosine kinases. ⁶
Crizotinib Data to be presented:
At the WCLC, data on the anti-tumor activity, safety, overall survival, patient-reported and quality-of-life outcomes observed in clinical trials of Pfizer’s crizotinib will be presented.^2,7,8

• Phase 2 data for crizotinib in ALK-positive advanced NSCLC: PROFILE 1005 (oral presentation, Abstract #1618, Wednesday, July 6)²
• PROFILE 1005: Preliminary patient-reported outcomes (PROs) from an ongoing Phase 2 study of crizotinib in ALK-positive advanced NSCLC (oral presentation, Abstract #1510, Wednesday, July 6)⁷
• Crizotinib improves overall survival of ALK-positive patients with advanced NSCLC compared with historical controls (oral presentation, Abstract #1207, Wednesday, July 6)⁸
• Efficacy of crizotinib in retrospective comparisons with standard-of-care (SOC) regimens from three Pfizer-sponsored clinical trials in patients with advanced NSCLC (poster session, Abstract #1349, Wednesday, July 6)⁹

Crizotinib is an investigational agent that inhibits ALK, ¹⁰ which blocks signaling in a number of cell pathways that are believed to be critical for the growth and survival of tumor cells.^11,12 Preliminary epidemiology suggests that approximately 3-5 percent of NSCLC tumors are ALK-positive.¹¹
About Pfizer Oncology
Pfizer Oncology is committed to the discovery, investigation and development of innovative treatment options to improve the outlook for cancer patients worldwide. Our strong pipeline, one of the most robust in the industry, is studied with precise focus on identifying and translating the best scientific breakthroughs into clinical application for patients across a wide range of cancers. Pfizer Oncology has biologics and small molecules in clinical development and more than 100 clinical trials underway. By working collaboratively with academic institutions, individual researchers, cooperative research groups, governments, and licensing partners, Pfizer Oncology strives to cure or control cancer with breakthrough medicines, to deliver the right drug for each patient at the right time. For more information please visit www.Pfizer.com.
DISCLOSURE NOTICE: The information contained in this release is as of June 28, 2011. Pfizer assumes no obligation to update forward-looking statements contained in this release as the result of new information or future events or developments.
This release contains forward-looking information about various oncology product candidates, including their potential benefits, that involves substantial risks and uncertainties. Such risks and uncertainties include, among other things, the uncertainties inherent in research and development; decisions by regulatory authorities regarding whether and when to approve any drug applications that have been or may be filed for any such oncology product candidates as well as their decisions regarding labeling and other matters that could affect their availability or commercial potential; and competitive developments.
A further description of risks and uncertainties can be found in Pfizer’s Annual Report on Form 10-K for the fiscal year ended December 31, 2010 and in its reports on Form 10-Q and Form 8-K.
¹ World Lung Accepted Abstract #745. Overall Survival (OS) Results of a Randomized Phase 2 Trial of PF299804 versus Erlotinib in Patients with Advanced Non-Small Cell Lung Cancer (NSCLC) After Failure of Chemotherapy. Oral Session, Monday July 4, 2011: 3:35 PM – 3:45 PM CEST. M. Boyer – Presenter. International Association for the Study of Lung Cancer’s (IASLC) 14th World Conference on Lung Cancer (WCLC), Amsterdam, The Netherlands. July 3-7, 2011.
² World Lung Accepted Abstract #1618. Phase 2 Data for Crizotinib (PF-02341066) in ALK-Positive Advanced Non-Small Cell Lung Cancer (NSCLC): PROFILE 1005. Oral Session, Wednesday July 6, 2011: 3:10 PM – 3:20 PM CEST. G. Riely – Presenter. International Association for the Study of Lung Cancer’s (IASLC) 14th World Conference on Lung Cancer (WCLC), Amsterdam, The Netherlands. July 3-7, 2011.
³ World Lung Accepted Abstract #957. Gastrointestinal Toxicity of the Pan-HER Tyrosine Kinase Inhibitor (TKI) PF299804: Assessment by Patient-Reported Outcomes in 2nd/3rd-Line and Refractory Non-Small Cell Lung Cancer (NSCLC). Poster Session, Wednesday July 6, 2011: 12:15 PM – 2:15 PM CEST. A. Campbell – Presenter. International Association for the Study of Lung Cancer’s (IASLC) 14th World Conference on Lung Cancer (WCLC), Amsterdam, The Netherlands. July 3-7, 2011.
⁴ World Lung Accepted Abstract #702. Dermatologic Adverse Events of the Pan-HER Tyrosine Kinase Inhibitor (TKI) PF299804: Assessment by Patient-Reported Outcomes in 2nd/3rd-line and Refractory Non-Small Cell Lung Cancer (NSCLC). Poster Session, Wednesday July 6, 2011: 12:15 PM – 2:15 PM CEST. A. Campbell – Presenter. International Association for the Study of Lung Cancer’s (IASLC) 14th World Conference on Lung Cancer (WCLC), Amsterdam, The Netherlands. July 3-7, 2011.
⁵ Clinicaltrials.gov. ARCHER 1009: A Phase 3 Study of PF-00299804, a Pan-HER Inhibitor, Vs. Erolotinib in the Treatment of Advanced Non-Small Cell Lung Cancer. Available here: http://www.clinicaltrials.gov/ct2/show/NCT01360554?term=ARCHER&rank=1. Accessed June 21, 2011.
⁶ Gonzales AJ, Hook KE, Althaus IW et al. Antitumor activity and pharmacokinetic properties of PF-00299804, a second-generation irreversible pan-erbBreceptor tyrosine kinase inhibitor. Mol Cancer Ther. 2008;7:1880-89.
⁷ World Lung Accepted Abstract #1510. PROFILE 1005: Preliminary Patient-Reported Outcomes (PROs) from an Ongoing Phase 2 Study of Crizotinib (PF-02341066) in Anaplastic Lymphoma Kinase (ALK)-Positive Advanced Non-Small Cell Lung Cancer (NSCLC). Oral Session, Wednesday July 6, 2011: 3:30 PM – 3:40 PM CEST. F. Blackhall – Presenter. Presenter. International Association for the Study of Lung Cancer’s (IASLC) 14th World Conference on Lung Cancer (WCLC), Amsterdam, The Netherlands. July 3-7, 2011.
⁸ World Lung Accepted Abstract #1207. Crizotinib improves overall survival of ALK-positive patients with advanced NSCLC compared with historical controls. Oral Session, Wednesday July 6, 2011: 3:20 PM – 3:30 PM CEST. A. Shaw – Presenter. International Association for the Study of Lung Cancer’s (IASLC) 14th World Conference on Lung Cancer (WCLC), Amsterdam, The Netherlands. July 3-7, 2011.
⁹ World Lung Accepted Abstract #1349. Efficacy of Crizotinib in Retrospective Comparisons with Standard-Of-Care (SOC) Regimens from Three Pfizer-Sponsored Clinical Trials in Patients with Advanced Non-Small Cell Lung Cancer (NSCLC). Poster Session, Wednesday July 6, 2011: 12:15 PM – 2:15 PM CEST. Y. Tang – Presenter. International Association for the Study of Lung Cancer’s (IASLC) 14th World Conference on Lung Cancer (WCLC), Amsterdam, The Netherlands. July 3-7, 2011.
¹⁰ Bang Y et al. Clinical Activity of the Oral ALK Inhibitor, Crizotinib (PF-02341066), in Patients with ALK-positive Non-Small Cell Lung Cancer. Accepted Plenary Presentation at the American Society of Clinical Oncology Annual Meeting, June 4-8, 2010. Chicago, IL.
¹¹ Zou HY, Li Q, Lee JH, et al. An orally available small-molecule inhibitor of c-MET,
PF-2341066, exhibits cytoreductive antitumor efficacy through antiproliferative and antiangiogenic mechanisms. Cancer Res. 2007;67:4408-4417.
¹² Chiarle R, Voena C, Ambrogio C et al. The anaplastic lymphoma kinase in the pathogenesis of cancer. Nat Rev Cancer. 2008;8(1): 11-23.

Related articles

• Pfizer Lung Cancer Drug to Get Priority Review (xconomy.com)
• Benefit of targeted lung cancer therapy confirmed (eurekalert.org)
• Pfizer drug shows double survival time for certain lung cancer patients (nj.com)
• Analyst bets on approval of Pfizer's lung cancer drug (fiercebiotech.com)

NOVEMBER 27, 2012 VITAMIN A

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" Seventy percent in life is showing up" - Woody Allen

You get an " A" for that. Honestly, there was a time I said I would show up and if I did it was by luck. I had no sense of responsibility. That changed almost 19 years ago. I show up today. I am there when I am asked to be there. Sometimes I am just there. I am a responsible human being, That is the way I conduct my life. That is one of the secrets of success. Be present for yourself and for others.

Very few of us today take separate Vitamin A. It is commonly in most of our multivitamins  and definitely present in Cod Liver Oil. Vitamin A deficiency can result in blindness and dryness of the eyes. The drying can result in corneal ulcers and infection. 

Also the lack of Vitamin A can result in squamous metaplasia. This is where there is a normal protection that is gone. The protection of these ciliated mucous membranes is absent in certain areas leading to squamous metaplasia which will then lead to cancer,
Vitamin A also has the distinction of being the anti infective vitamin. It is very useful in lung disorders as COPD ( emphysema, bronchitis and pneumonia)
As with the other fat soluble vitamins ( D, E and K) over dosage can lead to problems. I know a physician that prescribes it five days on and three days off. This is a good practice. The overdosage of vitamin A ( hypervitaminosis A) can present with band like headaches, nose bleeds, and even chapped lips.
There are some pediatricians who believe that Vitamin A protects children against otitis media ( middle ear infection)
Make sure your multi vitamin has Vitamin A. If not you can take an extra 10,000 IU without any adverse effects.
Until tomorrow...

Pfizer's To Present Lung Cancer Data July 3-7

To contact us Click HERE
Image via CrunchBase Pfizer Inc. will present early and mid-stage data from its lung cancer portfolio, including PF-00299804 (PF-299) an investigational, oral, pan-HER inhibitor;¹ and crizotinib, an investigational, oral, first-in-class compound that inhibits the anaplastic lymphoma kinase, or ALK,² at the International Association for the Study of Lung Cancer’s (IASLC) 14^th World Conference on Lung Cancer (WCLC), July 3-7 in Amsterdam, The Netherlands.

“While lung cancer remains a difficult-to-treat disease, we’re learning more about how therapies like crizotinib and PF-299 may be able to specifically target ALK or the HER pathway, respectively, and how this may lead to more rationally selected and personalized therapy,” said Maurizio Voi, MD, Thoracic Tumor Strategy Lead, Pfizer Oncology. “Data being presented show survival outcomes for PF-299 and crizotinib, as well as quality-of-life or patient-reported outcomes after treatment for patients with non small cell lung cancer, which represent important considerations in determining the best treatment option for these patients.”

First Presentation of PF-299 Preliminary Overall Survival Data

Continued....

 
Pfizer will present, for the first time, preliminary overall survival data from a Phase 2 study evaluating PF-299 vs erlotinib in patients with advanced non-small cell lung cancer (NSCLC) after progression on at least one chemotherapy regimen (oral presentation, Abstract #745, Monday, July 4).¹
Pfizer also will present patient-reported outcomes (PRO) from clinical trials of PF-299 in refractory and second-/third-line NSCLC, which provide a better understanding of the patient’s perspective of the burden of adverse events associated with treatment and how it may change over time.^3,4

• Gastrointestinal toxicity of the pan-HER tyrosine kinase inhibitor (TKI) PF299804: Assessment by patient-reported outcomes in second-/third-line and refractory NSCLC (poster session, Abstract #957, Wednesday, July 6)³
• Dermatologic adverse events of the pan-HER tyrosine kinase inhibitor (TKI) PF299804: Assessment by patient-reported outcomes in second-/third-line and refractory NSCLC (poster session, Abstract #702, Wednesday, July 6)⁴

Based on results from across the PF-299 clinical trial program, Pfizer has initiated a Phase 3 trial, ARCHER 1009, evaluating PF-299 vs erlotinib for the treatment of patients with locally advanced or metastatic NSCLC following progression after, or intolerance to, at least one prior chemotherapy. ARCHER 1009 will assess the efficacy and safety of PF-299 in two co-primary populations: all enrolled patients, and enrolled patients with KRAS wild type status. The ARCHER 1009 study is open for enrollment in the US and will be enrolling soon in other countries.⁵
PF-299 targets multiple receptors of the HER pathway. PF-299 is an irreversible inhibitor of HER-1 (EGFR), HER-2 and HER-4 tyrosine kinases. ⁶
Crizotinib Data to be presented:
At the WCLC, data on the anti-tumor activity, safety, overall survival, patient-reported and quality-of-life outcomes observed in clinical trials of Pfizer’s crizotinib will be presented.^2,7,8

• Phase 2 data for crizotinib in ALK-positive advanced NSCLC: PROFILE 1005 (oral presentation, Abstract #1618, Wednesday, July 6)²
• PROFILE 1005: Preliminary patient-reported outcomes (PROs) from an ongoing Phase 2 study of crizotinib in ALK-positive advanced NSCLC (oral presentation, Abstract #1510, Wednesday, July 6)⁷
• Crizotinib improves overall survival of ALK-positive patients with advanced NSCLC compared with historical controls (oral presentation, Abstract #1207, Wednesday, July 6)⁸
• Efficacy of crizotinib in retrospective comparisons with standard-of-care (SOC) regimens from three Pfizer-sponsored clinical trials in patients with advanced NSCLC (poster session, Abstract #1349, Wednesday, July 6)⁹

Crizotinib is an investigational agent that inhibits ALK, ¹⁰ which blocks signaling in a number of cell pathways that are believed to be critical for the growth and survival of tumor cells.^11,12 Preliminary epidemiology suggests that approximately 3-5 percent of NSCLC tumors are ALK-positive.¹¹
About Pfizer Oncology
Pfizer Oncology is committed to the discovery, investigation and development of innovative treatment options to improve the outlook for cancer patients worldwide. Our strong pipeline, one of the most robust in the industry, is studied with precise focus on identifying and translating the best scientific breakthroughs into clinical application for patients across a wide range of cancers. Pfizer Oncology has biologics and small molecules in clinical development and more than 100 clinical trials underway. By working collaboratively with academic institutions, individual researchers, cooperative research groups, governments, and licensing partners, Pfizer Oncology strives to cure or control cancer with breakthrough medicines, to deliver the right drug for each patient at the right time. For more information please visit www.Pfizer.com.
DISCLOSURE NOTICE: The information contained in this release is as of June 28, 2011. Pfizer assumes no obligation to update forward-looking statements contained in this release as the result of new information or future events or developments.
This release contains forward-looking information about various oncology product candidates, including their potential benefits, that involves substantial risks and uncertainties. Such risks and uncertainties include, among other things, the uncertainties inherent in research and development; decisions by regulatory authorities regarding whether and when to approve any drug applications that have been or may be filed for any such oncology product candidates as well as their decisions regarding labeling and other matters that could affect their availability or commercial potential; and competitive developments.
A further description of risks and uncertainties can be found in Pfizer’s Annual Report on Form 10-K for the fiscal year ended December 31, 2010 and in its reports on Form 10-Q and Form 8-K.
¹ World Lung Accepted Abstract #745. Overall Survival (OS) Results of a Randomized Phase 2 Trial of PF299804 versus Erlotinib in Patients with Advanced Non-Small Cell Lung Cancer (NSCLC) After Failure of Chemotherapy. Oral Session, Monday July 4, 2011: 3:35 PM – 3:45 PM CEST. M. Boyer – Presenter. International Association for the Study of Lung Cancer’s (IASLC) 14th World Conference on Lung Cancer (WCLC), Amsterdam, The Netherlands. July 3-7, 2011.
² World Lung Accepted Abstract #1618. Phase 2 Data for Crizotinib (PF-02341066) in ALK-Positive Advanced Non-Small Cell Lung Cancer (NSCLC): PROFILE 1005. Oral Session, Wednesday July 6, 2011: 3:10 PM – 3:20 PM CEST. G. Riely – Presenter. International Association for the Study of Lung Cancer’s (IASLC) 14th World Conference on Lung Cancer (WCLC), Amsterdam, The Netherlands. July 3-7, 2011.
³ World Lung Accepted Abstract #957. Gastrointestinal Toxicity of the Pan-HER Tyrosine Kinase Inhibitor (TKI) PF299804: Assessment by Patient-Reported Outcomes in 2nd/3rd-Line and Refractory Non-Small Cell Lung Cancer (NSCLC). Poster Session, Wednesday July 6, 2011: 12:15 PM – 2:15 PM CEST. A. Campbell – Presenter. International Association for the Study of Lung Cancer’s (IASLC) 14th World Conference on Lung Cancer (WCLC), Amsterdam, The Netherlands. July 3-7, 2011.
⁴ World Lung Accepted Abstract #702. Dermatologic Adverse Events of the Pan-HER Tyrosine Kinase Inhibitor (TKI) PF299804: Assessment by Patient-Reported Outcomes in 2nd/3rd-line and Refractory Non-Small Cell Lung Cancer (NSCLC). Poster Session, Wednesday July 6, 2011: 12:15 PM – 2:15 PM CEST. A. Campbell – Presenter. International Association for the Study of Lung Cancer’s (IASLC) 14th World Conference on Lung Cancer (WCLC), Amsterdam, The Netherlands. July 3-7, 2011.
⁵ Clinicaltrials.gov. ARCHER 1009: A Phase 3 Study of PF-00299804, a Pan-HER Inhibitor, Vs. Erolotinib in the Treatment of Advanced Non-Small Cell Lung Cancer. Available here: http://www.clinicaltrials.gov/ct2/show/NCT01360554?term=ARCHER&rank=1. Accessed June 21, 2011.
⁶ Gonzales AJ, Hook KE, Althaus IW et al. Antitumor activity and pharmacokinetic properties of PF-00299804, a second-generation irreversible pan-erbBreceptor tyrosine kinase inhibitor. Mol Cancer Ther. 2008;7:1880-89.
⁷ World Lung Accepted Abstract #1510. PROFILE 1005: Preliminary Patient-Reported Outcomes (PROs) from an Ongoing Phase 2 Study of Crizotinib (PF-02341066) in Anaplastic Lymphoma Kinase (ALK)-Positive Advanced Non-Small Cell Lung Cancer (NSCLC). Oral Session, Wednesday July 6, 2011: 3:30 PM – 3:40 PM CEST. F. Blackhall – Presenter. Presenter. International Association for the Study of Lung Cancer’s (IASLC) 14th World Conference on Lung Cancer (WCLC), Amsterdam, The Netherlands. July 3-7, 2011.
⁸ World Lung Accepted Abstract #1207. Crizotinib improves overall survival of ALK-positive patients with advanced NSCLC compared with historical controls. Oral Session, Wednesday July 6, 2011: 3:20 PM – 3:30 PM CEST. A. Shaw – Presenter. International Association for the Study of Lung Cancer’s (IASLC) 14th World Conference on Lung Cancer (WCLC), Amsterdam, The Netherlands. July 3-7, 2011.
⁹ World Lung Accepted Abstract #1349. Efficacy of Crizotinib in Retrospective Comparisons with Standard-Of-Care (SOC) Regimens from Three Pfizer-Sponsored Clinical Trials in Patients with Advanced Non-Small Cell Lung Cancer (NSCLC). Poster Session, Wednesday July 6, 2011: 12:15 PM – 2:15 PM CEST. Y. Tang – Presenter. International Association for the Study of Lung Cancer’s (IASLC) 14th World Conference on Lung Cancer (WCLC), Amsterdam, The Netherlands. July 3-7, 2011.
¹⁰ Bang Y et al. Clinical Activity of the Oral ALK Inhibitor, Crizotinib (PF-02341066), in Patients with ALK-positive Non-Small Cell Lung Cancer. Accepted Plenary Presentation at the American Society of Clinical Oncology Annual Meeting, June 4-8, 2010. Chicago, IL.
¹¹ Zou HY, Li Q, Lee JH, et al. An orally available small-molecule inhibitor of c-MET,
PF-2341066, exhibits cytoreductive antitumor efficacy through antiproliferative and antiangiogenic mechanisms. Cancer Res. 2007;67:4408-4417.
¹² Chiarle R, Voena C, Ambrogio C et al. The anaplastic lymphoma kinase in the pathogenesis of cancer. Nat Rev Cancer. 2008;8(1): 11-23.

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What's your Drinking Personality?

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The BBC is running a fluffy piece on peoples drinking personalities. It seems a psychologist, Dr. Glenn Willson, has observed the behavior of 500 Brits while at bars and pubs and found that their body language belies their personality. The good doctor has determined that their are eight distinct "drinking personalities". No more, no less.

From the article:

THE JACK-THE-LAD

This "peacock" is conscious of his image and will drink a bottled beer, or cider.

He is inclined to be confident and arrogant, and can be territorial in his gestures, spreading himself over as much space as possible, for example, pushing the glass well away from himself and leaning back in his chair.

If he is drinking with friends, he would be unlikely to welcome approaches from outside the group, unless sycophantic and ego-enhancing.

So, what's your drinking personality? I think I am clearly the "Ice Queen."

Image via the BBC.

NOVEMBER 26, 2012 OLIVE OIL

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" One of the most important things on any spiritual journey is our environment."

We as individuals must take care of our own environment. We need it more now than ever. If the devastating effects of Hurricane Sandy was not an indication, then YOU SHOULD WAKE UP. Earth Mother needs to be cared for and saved. If not more and more natural disasters will destroy our beautiful planet.


Did you have your olive oil today? I was probably bathed in olive oil as a child. The vegetable oils that predominantly monounsatured lead to a less cardiovascular risk than polyunsaturated. It was long ago that physicians did recommend those polyunsaturated oils to protect your heart. But as it turns out- That was WRONG. Margarine took the place of butter at that time. That was a big mistake. From research we know better today.

Do they still sell margarine ? I hope not.

The following oils do not pose a threat to the cardiovascular system
1. OLIVE
2. CANOLA
3. PEANUT
4. AVOCADO
There are differences in all four, and the one I prefer and highly recommend above all is OLIVE OIL. Due to the generosity of two friends, Carol and Aldo, we have a olive tree in Italy on a Olive Farm. During the year Rick and I receive olive oil from our own tree. It is the best

By replacing saturated fat in the diet with olive oil will reduce your LDL ( bad cholesterol). Who can argue with an oil that has been around for thousands of years. Our Italian olive oil from our tree is Extra-virgin.
This is extracted with gentle pressure rather than with heat or solvents. There are no pesticides strayed on our olive trees.

No matter what you decide , Olive Oil has the best correlation with health. The populations that use olive oil solely and mainly as their cooking fat oil have lower reductions in degenerative disease, cancer and cardiovascular disease.

If you replace butter ( and for those unfortunate that still use margarine) with olive oil you are making the first step to a healthier lifestyle.

So imagine this: combine olive oil in your diet daily with omega 3 fatty acids from good quality fish--and you will have longevity

Until tomorrow...